Thursday, February 28, 2013

AA's longest-serving flight attendant retires

A retirement party was held for an American Airlines flight attendant Barbara Beckett Monday as she celebrated her 53-year career with the company.

"It's something that I grew up wanting to do,? said Beckett, who is based in Miami. ?When I was very young my parents took me to the airport and I saw the stewardesses get off the plane. And I thought that's what I want to do.?

Beckett donned the American Airlines uniform for one last trip ? a last hurrah from Miami International Airport to London?s Heathrow Airport and back. Her flight was set to leave at 8 p.m.

Beckett has worked 8,000 flights for American, traveling the globe and going to places like Hawaii, Japan and Argentina.

The longest-serving flight attendant on American?s staff, she graduated from training on July 29, 1960, and has worked for the airline ever since.

Beckett?s longtime partner, her colleagues and friends, and some passengers wished her well at the gate before her Heathrow flight. Beckett said the first thing she wants to do once she retires is travel ? but she and her partner joked that she will be grounded for a while before booking a trip to Hawaii.

More from NBC Miami:

Source: http://www.nbcnews.com/travel/itineraries/american-airlines-longest-serving-flight-attendant-retires-after-53-years-1C8543813

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Sunday, February 24, 2013

Pope gives final Sunday blessing before resigning

In this photo provided by the Vatican newspaper L'Osservatore Romano, Pope Benedict XVI delivers his blessing during his last Angelus noon prayer, from the window of his studio overlooking St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/L'Osservatore Romano, ho)

In this photo provided by the Vatican newspaper L'Osservatore Romano, Pope Benedict XVI delivers his blessing during his last Angelus noon prayer, from the window of his studio overlooking St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/L'Osservatore Romano, ho)

Faithful hold up a banner with pictures of Pope Benedict XVI and writing reading in Italian "Thank you" as they attend Benedict's last Angelus prayer, in St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/Riccardo De Luca)

Faithful attend Pope Benedict XVI's last Angelus prayer, in St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/Riccardo De Luca)

Pope Benedict XVI delivers his blessing during his last Angelus noon prayer, from the window of his studio overlooking St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/Domenico Stinellis)

Nuns pray as they wait for Pope Benedict XVI's last Angelus prayer, in St. Peter's Square, at the Vatican, Sunday, Feb. 24, 2013. Benedict XVI gave his pontificate's final Sunday blessing from his studio window to the cheers of tens of thousands of people packing St. Peter's Square, but sought to reassure the faithful that he wasn't abandoning the church by retiring to spend his final years in prayer. The 85-year-old Benedict is stepping down on Thursday evening, the first pope to do so in 600 years, after saying he no longer has the mental or physical strength to vigorously lead the world's 1.2 billion Catholics. (AP Photo/Domenico Stinellis)

(AP) ? Pope Benedict XVI bestowed his final Sunday blessing of his pontificate on a cheering crowd in St. Peter's Square, explaining that his waning years and energy made him better suited to the life of private prayer he soon will spend in a secluded monastery than as leader of the Roman Catholic Church.

On Thursday evening, the 85-year-old German-born theologian will become the first pope to have resigned from the papacy in 600 years.

Sunday's noon appearance from his studio window overlooking the vast square was his next-to-last appointment with the public of his nearly eight-year papacy. Tens of thousands of faithful and other admirers have already asked the Vatican for a seat in the square for his last general audience Wednesday.

Perhaps emotionally buoyed by the warm welcome, thunderous applause and the many banners reading "Grazie" (Thanks) held up in the crowd estimated by police to number 100,000, Benedict looked relaxed and sounded energized, in sharp contrast to his apparent frailty and weariness of recent months.

In a strong and clear voice, Benedict told the pilgrims, tourists and Romans in the square that God had called him to dedicate himself "even more to prayer and meditation," which he will do in a monastery being renovated for him on the grounds behind Vatican City's ancient walls.

"But this doesn't mean abandoning the church," he said, as many in the crowd looked sad at his approaching departure. "On the contrary, if God asks me, this is because I can continue to serve it (the church) with the same dedication and the same love which I have tried to do so until now, but in a way more suitable to my age and to my strength."

The phrase "tried to" was the pope's adlibbed addition to his prepared text.

Benedict smiled in pleasure at the crowd after an aide parted the white curtain at his window and he gazed at the people packing the square, craning their head for a look at him. Giving greetings in several languages, he gratefully acknowledged what he said was an outpouring of "gratitude, affection and closeness in prayer" since he stunned the church and its 1.2 billion members on Feb. 11 with his decision to renounce his papacy and retreat into a world of contemplation.

"Prayer is not isolating oneself from the world and its contradictions," Benedict told the crowd. He said he had heard God's call to prayer, "which gives breath to our spiritual life" in a special way "at this moment of my life."

Heavy rain had been forecast for Rome, and some drizzle dampened the square earlier in the morning. But when Benedict appeared, to the peal of church bells as the clock struck noon, blue sky crept through the clouds.

"We thank God for the sun he has given us," the pope said.

Even as the cheering continued and shouts of "Long live the pope" went up in Italian and Spanish, the pontiff simply turned away from his window and stepped back down into the apartment, which he will leave Thursday, taking a helicopter to the Vatican summer residence in the hills outside Rome while he waits for the monastery to be ready.

A child in the crowd held up a sign on a yellow placard, written in Italian, "You are not alone, I'm with you."

No date has yet been set for the start of the conclave of cardinals, who will vote in secret to elect Benedict's successor.

"Now there will be two popes," said the Rev. Vilmar Pavesi, a Portuguese priest who was among the throngs in the square. "There will be the pope of Rome, the elected pope, and there will be the bishop emeritus of Rome, who will live the life of a monk inside the Vatican walls."

One Italian in the crowd seemed to be doing a little campaigning, hoisting a sign which mentioned the names of two Italian cardinals considered by observers to be potential contenders in the selection of the next pontiff.

Flags in the crowd represented many nations, with a large number from Brazil.

The cardinals in the conclave will have to decide whether it's time to look outside of Europe for a pope. The papacy was considered the realm of Italian prelates for centuries, until a Pole, John Paul II, was elected as pontiff in 1978, to be followed in 2005 by the German-born Benedict.

Crucially, Italian prelates have continued to run the behind-the-scenes machinery of the church's governance, and cardinals will likely be deciding what role the Italians might have played in a series of scandals clouding the central bureaucracy, including allegations of corruption and power-grabbing.

Benedict has not made any direct comment on details of the scandals.

In one of his last papal tweets, Benedict wrote Sunday in English: "In these momentous days, I ask you to pray for me and for the church, trusting as always in divine providence."

___

AP reporter Paolo Santalucia contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-24-EU-Vatican-Pope/id-15e56d15320841a498784a0eae2833d3

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Watershed elections in Italy

Supporters wait for Italian comic-turned-political agitator Beppe Grillo, leader of the anti-establishment 5 Star Movement, to deliver his speech at a final rally in view of the upcoming general elections, in Rome, Friday, Feb. 22, 2013. Grillo fills piazzas from Milan to Rome, from Palermo to Verona with Italians who seem to get some catharsis from his rant against politician who drove the country to the brink of financial ruin, industrial managers whose alleged shenanigans are tarnishing prized companies and bankers who aided and abetted the other two classes of powerbrokers. (AP Photo/Andrew Medichini)

Supporters wait for Italian comic-turned-political agitator Beppe Grillo, leader of the anti-establishment 5 Star Movement, to deliver his speech at a final rally in view of the upcoming general elections, in Rome, Friday, Feb. 22, 2013. Grillo fills piazzas from Milan to Rome, from Palermo to Verona with Italians who seem to get some catharsis from his rant against politician who drove the country to the brink of financial ruin, industrial managers whose alleged shenanigans are tarnishing prized companies and bankers who aided and abetted the other two classes of powerbrokers. (AP Photo/Andrew Medichini)

Italian comic-turned-political agitator Beppe Grillo, leader of the anti-establishment 5 Star Movement, delivers his speech during a final rally in view of the upcoming general elections, in Rome, Friday, Feb. 22, 2013. Grillo fills piazzas from Palermo deep in the south to Verona up north with Italians who seem to get some catharsis from his rants against the politicians who drove the country to the brink of financial ruin, the captains of industry whose alleged illegal shenanigans are tarnishing prized companies, and the bankers who aided and abetted both. (AP Photo/Andrew Medichini)

Italian center-left coalition leader Pierluigi Bersani delivers his speech during a campaign rally in Rome, Friday, Feb. 22, 2013. Amid corruption scandals, rising populist sentiment and financial hardship, Italians are voting in a watershed parliamentary election Sunday and Monday seen as a test of their will to stay the course for painful economic reforms or revert to their free spending ways of the past. Silvio Berlusconi, a billionaire forced out of office by Italy's debt crisis, is seeking a political comeback promising Italians to give them back the real estate tax they paid as part of austerity measures enacted to salvage the economy. (AP Photo/Gregorio Borgia)

Supporters wave flags in front of a giant monitor broadcasting a message by Silvio Berlusconi during a center-right coalition rally in Naples, Italy, Friday, Feb. 22, 2013. Silvio Berlusconi has skipped his last campaign rally before Italian elections because of an eye problem. The 76-year-old media mogul is trying to make a comeback, to win a fourth term as premier. He was supposed to address a rally in Naples on Friday, but instead spoke to supporters in a video message. Italian media quoted his personal doctor, Alberto Zangrillo, as saying Berlusconi was advised to skip the rally, because he has a posterior vitreous detachment in an eye. In the condition, common in the elderly, a gel-like substance naturally in the eye pulls away from the retina. (AP Photo/Salvatore Laporta)

Italian center-left coalition leader Pierluigi Bersani delivers his speech during a campaign rally in Rome, Friday, Feb. 22, 2013. Amid corruption scandals, rising populist sentiment and financial hardship, Italians are voting in a watershed parliamentary election Sunday and Monday seen as a test of their will to stay the course for painful economic reforms or revert to their free spending ways of the past. Silvio Berlusconi, a billionaire forced out of office by Italy's debt crisis, is seeking a political comeback promising Italians to give them back the real estate tax they paid as part of austerity measures enacted to salvage the economy. (AP Photo/Gregorio Borgia)

(AP) ? Will Italy stay the course with painful economic reform? Or fall back into the old habit of profligacy and inertia? These are the stakes as Italy votes in a watershed parliamentary election Sunday and Monday that could shape the future of one of Europe's biggest economies.

Fellow EU countries and investors are watching closely, as the decisions that Italy makes over the next several months promise to have a profound impact on whether Europe can decisively put out the flames of its financial crisis. Greece's troubles in recent years were enough to spark a series of market panics. With an economy almost 10 times the size of Greece's, Italy is simply too big a country for Europe, and the world, to see fail.

Leading the electoral pack is Pier Luigi Bersani, a former communist who has shown a pragmatic streak in supporting tough economic reforms spearheaded by incumbent Mario Monti. On Bersani's heels is Silvio Berlusconi, the billionaire media mogul seeking an unlikely political comeback after being forced from the premiership by Italy's debt crisis. Monti, while widely credited with saving Italy from financial ruin, is trailing badly as he pays the price for the suffering caused by austerity measures.

Then there's the wild card: comic-turned-politician Beppe Grillo, whose protest movement against the entrenched political class has been drawing tens of thousands to rallies in piazzas across Italy. If his self-styled political "tsunami" sweeps into Parliament with a big chunk of seats, Italy could be in store for a prolonged period of political confusion that would spook the markets.

While a man of the left, Bersani has shown himself to have a surprising amount in common with the center-right Monti ? and the two have hinted at the possibility of teaming up in a coalition. Bersani was Monti's most loyal backer in Parliament during the respected economist's tenure at the head of a technocratic government. And in ministerial posts in previous center-left governments, Bersani fought hard to free up such areas of the economy as energy, insurance and banking services.

But it's uncertain that Monti will be able muster the votes needed to give Bersani's Democratic Party a stable majority in both houses of Parliament.

"Forming a government with a stable parliamentary alliance may prove tricky after elections," said Eoin Ryan, an analyst with IHS Global Insight. "A surge in support for anti-austerity parties is raising chances of an indecisive election result and post-vote political instability."

Another factor is turnout. Usually some 80 percent of the 50 million eligible voters go to the polls but experts are predicting many will stay away in anger, hurting mainstream parties.

When Berlusconi stepped down in November 2011, newspapers were writing his political obituary. At 76, blamed for mismanaging the economy and disgraced by criminal allegations of sex with an underage prostitute, the billionaire media baron appeared finished as a political force.

But Berlusconi has proven time and again ? over 20 years at the center of Italian politics ? that he should never be counted out.

The campaign strategy that has allowed him to become a contender in these elections is a simple one: please the masses by throwing around cash.

Berlusconi has promised to give back an unpopular property tax imposed by Monti as part of austerity measures. Even his purchase of start striker Mario Balotelli for his AC Milan soccer team was widely seen as a ploy to buy votes. Berlusconi has also appealed to Italy's right-wing by praising Italy's former fascist dictator Benito Mussolini during a ceremony commemorating Holocaust victims.

The most recent polls show Bersani in the lead with 33 percent of the vote, against 28 percent for Berlusconi's coalition with the populist Northern League. Grillo's 5 Star movement was in a surprise third place, with 17 percent support, while Monti's centrist coalition was notching 13 percent. The COESIS poll of 6,212 respondents had a margin of error of plus or minus 1.2 percent.

Pollster Renato Mannheimer said among his biggest clients heading into the elections were foreign banks seeking to gauge whether to hold or sell Italian bonds.

"They are worried mostly about the return of Berlusconi," Mannheimer said.

Uncertainty over the outcome of the vote has pushed the Milan stock exchange down in the days running up to the vote and bumped up borrowing costs, as investors express concern that Italy may back down from a reform course to pull the country out of recession.

Mannheimer said many undecided voters ? who comprise around one-third of the total electorate ? identify with the center-right, and that may help Berlusconi. He said that the undecided vote may also tilt heavily toward Grillo's protest movement.

The professorial Monti looked uncomfortable at first as a candidate but has recently warmed to the role. Like the others, he has not shied away from name calling, warning that Berlusconi is a "charlatan" and saying his return would be "horrific."

Bond analyst Nicholas Spiro said the election "will deliver the most important verdict on the eurozone's three-year-old austerity focused policies."

But he is betting on a period of political instability after the vote.

"An upset victory by Mr. Berlusconi may be markets' nightmare scenario," he said, "but the prospects for a stable and harmonious Bersani-Monti coalition government ? still the mostly likely outcome in our view ? are bleak."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-24-Italy-Elections/id-088f295854684a3ead0bd781bb4aed74

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Canada: Religious office a great investment


This office is Canada?s $5-million investment in humanity, its gift to the global village, and a bold message to Canadians: as world citizens and members of a peacekeeping nation, we cannot ignore what transpires in other countries. Ahmadiyya Times | News Watch |
Source/Credit: National Post
By Mohsina Islam | February 22, 2013

Re: Hearing The Call Of A Higher (Political) Power, Kelly McParland, Feb. 21.

Canada?s Office of Religious Freedom will probably not end religious persecution that occurs on foreign soil, but God willing, it will make an indelible and positive mark on humanity for centuries to come. The atrocities that occur when religious freedom is suppressed are real and ghastly. Sadly, we have lost sense of their ghastliness due to censorship, which allows us to turn a blind eye to reality.

This office is Canada?s $5-million investment in humanity, its gift to the global village, and a bold message to Canadians: as world citizens and members of a peacekeeping nation, we cannot ignore what transpires in other countries.

Mohsina Islam, Brampton, Ont.

Read original post here:?Canada: Religious office a great investment

This content-post is archived for backup and to keep archived records of any news Islam Ahmadiyya. The views expressed by the author and source of this news archive do not necessarily reflect the views and policies of Ahmadiyya Times.

Source: http://ahmadiyyatimes.blogspot.com/2013/02/canada-religious-office-great-investment.html

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Brazil to Host New Green Energy Trade Show: The trade show will showcase the ra...

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Source: http://www.facebook.com/thomasnetnews/posts/129142100596947

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Saturday, February 23, 2013

Sony, resmi olarak Olympus'un en b?y?k hissedar? durumuna geldi

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Foto?raf d?nyas?n?n b?y?k isimlerinden Olmypus bug?n yapt??? resmi a??klama ile Sony firmas?n?n, kendi hisse pay? i?erisinde, en b?y?k hisseye sahip firma durumuna geldi?ini a??klad?.

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Ge?ti?imiz sene ilk haberleri ??kan Sony-Olympus anla?mas?, bug?n Olympus taraf?ndan yap?lan resmi a??klama ile kesinle?mi? oldu. Yap?lan duyuru sonucunda Sony, Olympus'un en b?y?k hisse sahibi firma durumuna toplam 610 milyon dolar yat?r?m ile gelerek, firman?n 35 milyona yak?n hissesine ve firma i?i genel oy hakk?n?n da %11.46'l?k k?sm?na sahip oldu.

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Yap?lan bu anla?ma sonucunda iki firma aras?nda ?zellikle t?bbi ve g?r?nt?leme teknolojileri a??s?ndan i?birli?i ve teknoloji payla??m? a??s?ndan yenilikler olaca?? belirtiliyor.

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http://www.amateurphotographer.co.uk/photo-news/539503/sony-becomes-main-olympus-shareholder?

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Source: http://www.donanimhaber.com/Sony_resmi_olarak_Olympusun_en_buyuk_hissedari_durumuna_geldi-40224.htm

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Egypt opposition leader calls for election boycott

FILE - In this Saturday, Nov. 24, 2013 file photo, leading democracy advocate Mohammed ElBaradei speaks to a handful of journalists including the Associated Press, at his home on the outskirts of Cairo, Egypt. Mohamed ElBaradei, who leads the main opposition National Salvation Front, wrote on Twitter Saturday, Feb. 23, 2013 that he is calling for the boycott "to expose sham democracy," as he said he did in a similar call in 2010 under then-president Hosni Mubarak. ElBaradei says he urges the boycott of the vote called by Islamist President Mohammed Morsi because he "will not be part of an act of deception."(AP Photo/Thomas Hartwell, File)

FILE - In this Saturday, Nov. 24, 2013 file photo, leading democracy advocate Mohammed ElBaradei speaks to a handful of journalists including the Associated Press, at his home on the outskirts of Cairo, Egypt. Mohamed ElBaradei, who leads the main opposition National Salvation Front, wrote on Twitter Saturday, Feb. 23, 2013 that he is calling for the boycott "to expose sham democracy," as he said he did in a similar call in 2010 under then-president Hosni Mubarak. ElBaradei says he urges the boycott of the vote called by Islamist President Mohammed Morsi because he "will not be part of an act of deception."(AP Photo/Thomas Hartwell, File)

FILE - In this July 13, 2012 file photo, Egyptian President Mohammed Morsi speaks to reporters at the Presidential palace in Cairo. An Egyptian opposition group has found a novel way of protesting the rule of President Mohammed Morsi: It signed him up for a chance to win a trip to space. The April 6 Youth Movement said on its official Facebook page on Thursday, Feb. 21, 2013 that it entered the Islamist leader?s name in the on-lined context launched by a U.S. men?s personal company because it wanted to be rid of him. It called on supporters to vote for the president. (AP Photo/Maya Alleruzzo, File)

FILE - In this Tuesday, Nov. 13, 2012 file photo, released by the Egyptian Presidency, Nobel Peace Prize winner and head of the opposition Egyptian Constitution political party, Mohamed ElBaradei, left, meets with Egyptian President Mohammed Morsi, in Cairo, Egypt. An Egyptian opposition leader is calling for a boycott of upcoming parliamentary elections, a day after he said the vote will inflame the country's political tensions. Mohamed ElBaradei, who leads the main opposition National Salvation Front, wrote on Twitter Saturday, Feb. 23, 2013 that he is calling for the boycott "to expose sham democracy," as he said he did in a similar call in 2010 under then-president Hosni Mubarak. ElBaradei says he urges the boycott of the vote called by Islamist President Mohammed Morsi because he "will not be part of an act of deception." (AP Photo/Egyptian Presidency, File)

An Egyptian man with his three children wear red during a symbolic hanging at an anti-government protest in front of Egypt's high court building in downtown Cairo, Friday, Feb. 22, 2013. The Arabic writing on the banners reads, "death is more honorable for me and my children than poverty and hunger," and " Jeeka, Christy and Mohammed to heaven." Egypt's president called multi-stage parliamentary elections beginning in April but a key opposition leader warned Friday that the vote may only inflame tensions unless there are serious political talks first.(AP Photo/Khalil Hamra)

(AP) ? Egyptian opposition leader Mohamed ElBaradei called Saturday for a boycott of parliamentary elections, drawing immediate criticism from some within his movement who said it was a hasty decision.

The dispute showed the fragility of a fairly new opposition front forged after the deeply fragmented movement found little success at the polls since it led the 2011 uprising that ousted autocrat Hosni Mubarak.

Opposition infighting would only help ensure that the Islamist Muslim Brotherhood group remains Egypt's dominant political force after the next vote.

"(I) called for parliamentary election boycott in 2010 to expose sham democracy. Today I repeat my call, will not be part of an act of deception," Nobel laureate ElBaradei, who leads the opposition National Salvation Front (NSF), wrote on his Twitter account.

The comment reiterated a frequently heard opposition sentiment that democratically elected President Mohammed Morsi is acting like Mubarak.

Elections under Mubarak's three-decade rule were widely rigged and parliament was dominated by members of his ruling party.

Morsi called for the elections in a decree late Thursday night ? a four-stage vote starting at the end of April and concluding in June.

On Friday, ElBaradei said holding elections during this time of deep political polarization "is a recipe for disaster."

Morsi's Brotherhood accused the opposition of running away from the challenge.

The deputy head of the Brotherhood's Freedom and Justice Party, Essam el-Erian, responded to ElBaradei's call on his Facebook page.

"Running away from a popular test only means that some want to assume executive authority without a democratic mandate," he said of the opposition. "We've never yet known them to face any election or serious test."

The mutual recriminations reflected a new escalation in political tensions that could spill into even wider strikes and protests ahead of the elections.

The opposition has accused Morsi and his Brotherhood backers of using election wins to monopolize power in tactics similar to the former regime.

They accuse Morsi of reneging on a promise to form an inclusive government representative of the Christian minority, women, and liberals.

In the country's last major vote, a hotly disputed constitutional referendum in December, ElBaradei urged his supporters at the last minute to participate and vote "No" after a debate within the opposition over whether to boycott.

The referendum was mired in controversy and rights groups criticized unchecked voting irregularities.

The Islamists, accused of ramming the charter through a drafting panel that they dominated, won passage by more than 60 percent, but turnout was low around 30 percent. Critics said the document opened the way for imposing Islamic law more strictly in Egypt.

Tensions soared in the run-up to the vote, with violent clashes between pro- and anti-government protesters that led to bloodshed outside the presidential palace.

Almost immediately after ElBaradei's boycott call, rifts began to emerge in the opposition. Even members of his opposition bloc, the NSF, said the group had not yet decided on a boycott.

Some activists criticized the call, saying it would alienate the masses and allow the Brotherhood free rein over the lower house of parliament, which writes laws and is supposed to monitor the president.

The Brotherhood already has the most seats in the upper chamber of parliament, largely an advisory body currently serving as an interim parliament. And it also successfully fielded Morsi as its candidate for president.

In Egypt's first free elections in 2011, the Brotherhood won nearly half of seats in parliament and the more conservative Islamists known as Salafis won a quarter.

A splinter Salafi party has emerged since then and competition for seats is expected to be fierce, particularly in Egypt's vast rural areas and poor city slums.

Within months of being elected, the lower house of parliament was disbanded in June of last year after the Supreme Constitutional Court ruled that a third of the chamber's members were elected illegally.

The upcoming elections are to reinstate the legislature.

Liberal and secular parties have trailed significantly in all elections since Mubarak was toppled. Their outreach across Egypt, while growing, is still dwarfed by the Islamists' well organized network of charities and programs that assist the poor.

But at the same time, since Morsi's election as Egypt's first civilian and Islamist president last summer, his popularity has eroded.

Blogger and commentator Mahmoud Salem, a longtime activist who now opposes Morsi, said he disagreed with a boycott because it offers no real alternative to the political impasse.

"Where's ElBaradei's party, its plan, its economic vision? Let's say a boycott is the right answer. What will they do so that they can be competitive in the next election?" Salem said.

He accused ElBaradei of calling for a boycott in part because the opposition has been unable to win significantly at the polls.

"In reality, it will end up as a parliament composed of the Muslim Brotherhood, the Salafis, or members of the ex-regime," he said.

Others have said they may enter elections, but are criticizing Morsi's timing.

Shadi Taha, a leading figure of al-Ghad al-Thawra party led by former Mubarak rival Ayman Nour, told The Associated Press that the country should be focused first on more pressing issues like the economy, education and health care.

The party has not yet decided if it will boycott.

"The last thing we need is to enter a new cycle that further polarizes and splits the country," Taha said. "First there should be stability. ... Elections should have been delayed to deal with bigger priorities."

On the second anniversary of the Jan. 25 uprising this year, anger at police impunity for abuses and an array of other social woes spilled out onto the streets and violence again engulfed the nation.

About 70 people died in a wave of protests and riots since then ? more than half of them in the restive Suez Canal city of Port Said alone.

A civil disobedience campaign in Port Said entered its seventh day on Saturday. The protesters are demanding retribution for those killed during the recent unrest. There have also been near daily protests in Cairo and in the textile producing city of Mahalla.

Former lawmaker Mostafa al-Naggar, a centrist, said boycott calls will be ineffective unless there is unity among the opposition.

He wrote on Twitter that a boycott "will clear the arena for the ruling party and its allies to dominate the legislative and executive branches."

ElBaradei's opposition coalition, which was only formed late last year, had warned for weeks it could boycott if certain conditions were not met first.

The NSF said it wants a real national dialogue that leads to the formation of a more inclusive government, changes to the constitution and stability.

Egypt's new constitution, approved in late December, says that procedures for elections should begin within two months of the charter being ratified but does not set a deadline for the vote.

Egypt's Coptic Christians complained that elections start around Palm Sunday and Easter, prompting Morsi to review the timing of the vote. Minority Christians have consistently voted against the Brotherhood.

On Saturday, Morsi changed the start of voting to April 22 instead of April 28.

Morsi's supporters say that delaying elections, protesting and boycotting are affecting Egypt's ability to lure foreign investors and tourists again as the economy deteriorates.

Egypt's oldest opposition party, al-Wafd, steered clear of immediately supporting a boycott. Instead, the party said it will file a lawsuit against elections being announced before laws governing the vote are approved.

Former liberal lawmaker Amr Hamzawi , part of ElBaradei's NSF group, told the AP that a boycott might be a good option but ElBaradei's unilateral call may have come prematurely.

"I don't think we need to decide today. But we need to enter a process of collective reflection," he said. "It takes time" for any opposition to translate its movement into societal change and elections victories.

___

Mosaad el-Gohary in Port Said contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-23-Egypt/id-0177d51a8f534f328836d0ce2f68f5be

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Friday, February 22, 2013

THE RESET: Obama, GOP battles don't affect Fed job

While the White House and Congress lurch combatively from one budget crisis to the next, another Washington institution has been bolstering the economy steadily and with little fanfare since the 2008 financial crisis began.

And the Federal Reserve seems likely to keep its stimulus pumps running at least awhile longer ? although minutes from a recent meeting show growing nervousness among U.S. central bankers over possible long-range harmful consequences, including steep inflation and instability in financial markets.

The Fed, under Chairman Ben Bernanke, has been keeping a key short-term interest rate near zero for over four years and is buying tens of billions of dollars in Treasury and mortgage bonds a month to keep downward pressure on longer-term interest rates and to provide liquidity to financial institutions.

Oh, and it's buying those bonds with money created out of thin air with the electronic equivalent of a printing press.

Minutes from the Fed's Jan. 29-30 policy meeting showed increasing debate over whether to end the huge stimulus sooner rather than later.

Still, the Fed voted 11-1 to continue its $85-billion monthly bond buying program for now.

However, the concerns were enough to drive European stocks sharply lower Thursday and contributed to a second day of declines for U.S. stocks ? even though there's scant evidence of rising inflation.

U.S. consumer prices were flat last month, a new government report shows, another sign inflation remains in check.

The latest crisis for President Barack Obama and Congress is the approach of deep, mandatory "sequester" spending cuts due to hit March 1 absent a bipartisan deficit-reduction deal. So far Republicans who lead the House have rejected Obama's insistence that any agreement be "balanced" with both spending cuts and increased tax revenues.

U.S. policymakers barely averted a "fiscal cliff" at the end of last year.

"Managing from crisis to crisis every 60 to 90 days is absurd," House Minority Whip Steny Hoyer, D-Md., said Thursday on MSNBC.

___

Follow Tom Raum on Twitter: http://www.twitter.com/tomraum

Source: http://news.yahoo.com/reset-obama-gop-battles-dont-affect-fed-job-173745176--politics.html

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Monday, February 18, 2013

New study on Hepatitis C drug treatment in vivo and in vitro

New study on Hepatitis C drug treatment in vivo and in vitro [ Back to EurekAlert! ] Public release date: 18-Feb-2013
[ | E-mail | Share Share ]

Contact: Stasia Thompson
thoms@lumc.edu
708-216-5155
Loyola University Health System

Loyola researchers show daclatasvir has 2 modes of action

Hepatitis C virus (HCV) infection affects about 4.1 million in the United States and is the primary cause of liver cirrhosis and liver cancer. Current therapy against HCV is suboptimal. Daclatasvir, a direct acting antiviral (DAA) agent in development for the treatment of HCV, targets one of the HCV proteins (i.e., NS5A) and causes the fastest viral decline (within 12 hours of treatment) ever seen with anti-HCV drugs. An interdisciplinary effort by mathematical modelers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life.

Results of the NS5A study are published in the prestigious Proceedings of the National Academy of Sciences (PNAS) on February 18th, 2013.

"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeler Harel Dahari, Ph.D, who co-led the study. Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, MD who authored the study along with Thomas Layden, MD, HCV virologist Susan L. Uprichard, Ph.D and Dr. Uprichard's Ph.D graduate student Natasha Sansone. The study was co-led with Dr. Jeremie Guedj (Institut National de la Sant et de la Recherche Mdicale), and conducted with Drs. Alan Perelson (Senior Fellow at Los Alamos National Laboratory), Libin Rong (Oakland University) and Richard Nettles (Bristol-Myers Squibb).

The new study documents HCV kinetic modeling during treatment both in patients and in cell culture that provides insight into the modes of action of daclatasvir. In addition, the study suggests a more accurate estimate of HCV clearance from circulation previously estimated in 1998 by Drs. Dahari, Layden, Perelson and colleagues in Science.

"Our modeling of viral kinetics in treated patients predicts that daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also blocks the secretion of infectious virus from the cells," explained Dahari. This prediction was confirmed in Dr. Uprichard's laboratory using cultured liver cells that support the entire life cycle of HCV infection. Drs. Dahari and Uprichard are directors of a new program for experimental and translational modeling recently established at Loyola to promote the type of interdisciplinary research exemplified in this publication.

Additional 2013 Dahari Research Papers

Additional research conducted by Dahari and colleagues related to the new Loyola program for experimental and translational modeling are in press for publication in other professional journals:

  • A study on the effect of ribavirin on HCV kinetics and liver gene expression, led by researchers from the National Institute of Health and published in Gut.
  • A letter on understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling, published in the Journal of Hepatology.
  • A study showcasing a mathematical model of the acute and chronic phases of Theiler murine encephalomyelitis virus (TMEV) infection that can serve as an important tool in understanding TMEV infectious mechanisms and may prove useful in evaluating antivirals and/or therapeutic modalities to prevent or inhibit demyelination multiple sclerosis, published in the Journal of Virology.

Dr Dahari is a recognized international leader in the field of viral kinetics. "Loyola is honored to have Dr. Dahari as a member of the Hepatology faculty; his ground-breaking research will help reinforce Loyola's leadership in the treatment of hepatitis C," said David Hecht, MD, interim senior vice president, Clinical Affairs at LUHS and Chair of Internal Medicine in the SSOM.

###

Hepatology at Loyola

Loyola University Health System has expanded hepatology services with physicians now available in Moline, Peoria, Rockford, Burr Ridge, Park Ridge, Homer Glen and Maywood, as well as in the Dearborn Station building in the South Loop and in Chicago's Chinatown neighborhood.

To make an appointment with a Loyola hepatologist, call 85-LIVERDOC (855-483-7362. To make an appointment online, please visit loyolamedicine.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New study on Hepatitis C drug treatment in vivo and in vitro [ Back to EurekAlert! ] Public release date: 18-Feb-2013
[ | E-mail | Share Share ]

Contact: Stasia Thompson
thoms@lumc.edu
708-216-5155
Loyola University Health System

Loyola researchers show daclatasvir has 2 modes of action

Hepatitis C virus (HCV) infection affects about 4.1 million in the United States and is the primary cause of liver cirrhosis and liver cancer. Current therapy against HCV is suboptimal. Daclatasvir, a direct acting antiviral (DAA) agent in development for the treatment of HCV, targets one of the HCV proteins (i.e., NS5A) and causes the fastest viral decline (within 12 hours of treatment) ever seen with anti-HCV drugs. An interdisciplinary effort by mathematical modelers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life.

Results of the NS5A study are published in the prestigious Proceedings of the National Academy of Sciences (PNAS) on February 18th, 2013.

"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeler Harel Dahari, Ph.D, who co-led the study. Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, MD who authored the study along with Thomas Layden, MD, HCV virologist Susan L. Uprichard, Ph.D and Dr. Uprichard's Ph.D graduate student Natasha Sansone. The study was co-led with Dr. Jeremie Guedj (Institut National de la Sant et de la Recherche Mdicale), and conducted with Drs. Alan Perelson (Senior Fellow at Los Alamos National Laboratory), Libin Rong (Oakland University) and Richard Nettles (Bristol-Myers Squibb).

The new study documents HCV kinetic modeling during treatment both in patients and in cell culture that provides insight into the modes of action of daclatasvir. In addition, the study suggests a more accurate estimate of HCV clearance from circulation previously estimated in 1998 by Drs. Dahari, Layden, Perelson and colleagues in Science.

"Our modeling of viral kinetics in treated patients predicts that daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also blocks the secretion of infectious virus from the cells," explained Dahari. This prediction was confirmed in Dr. Uprichard's laboratory using cultured liver cells that support the entire life cycle of HCV infection. Drs. Dahari and Uprichard are directors of a new program for experimental and translational modeling recently established at Loyola to promote the type of interdisciplinary research exemplified in this publication.

Additional 2013 Dahari Research Papers

Additional research conducted by Dahari and colleagues related to the new Loyola program for experimental and translational modeling are in press for publication in other professional journals:

  • A study on the effect of ribavirin on HCV kinetics and liver gene expression, led by researchers from the National Institute of Health and published in Gut.
  • A letter on understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling, published in the Journal of Hepatology.
  • A study showcasing a mathematical model of the acute and chronic phases of Theiler murine encephalomyelitis virus (TMEV) infection that can serve as an important tool in understanding TMEV infectious mechanisms and may prove useful in evaluating antivirals and/or therapeutic modalities to prevent or inhibit demyelination multiple sclerosis, published in the Journal of Virology.

Dr Dahari is a recognized international leader in the field of viral kinetics. "Loyola is honored to have Dr. Dahari as a member of the Hepatology faculty; his ground-breaking research will help reinforce Loyola's leadership in the treatment of hepatitis C," said David Hecht, MD, interim senior vice president, Clinical Affairs at LUHS and Chair of Internal Medicine in the SSOM.

###

Hepatology at Loyola

Loyola University Health System has expanded hepatology services with physicians now available in Moline, Peoria, Rockford, Burr Ridge, Park Ridge, Homer Glen and Maywood, as well as in the Dearborn Station building in the South Loop and in Chicago's Chinatown neighborhood.

To make an appointment with a Loyola hepatologist, call 85-LIVERDOC (855-483-7362. To make an appointment online, please visit loyolamedicine.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/luhs-nso021513.php

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Tiger Woods joins vacationing Obama for golf round

PALM CITY, Fla. (AP) ? President Barack Obama played golf Sunday with Tiger Woods, the White House said.

Once the sport's dominant player before his career was sidetracked by scandal, Woods joined Obama at the Floridian, a secluded and exclusive yacht and golf club on Florida's Treasure Coast where Obama is spending the long Presidents Day weekend. The two had met before, but Sunday was the first time they played together.

The White House, which has promised to be the most open and transparent in history, has prohibited any media coverage of Obama's golf outing.

The foursome also included Jim Crane, a Houston businessman who owns the Floridian and baseball's Houston Astros, and outgoing U.S. Trade Representative Ron Kirk, a former mayor of Dallas, said White House spokesman Josh Earnest. Crane and Kirk also were part of Obama's foursome on Saturday, the White House said.

Obama, an avid golfer, also received some instruction Saturday and played a few holes with Butch Harmon, Woods' former swing coach.

Initial word that the First Duffer would play a round with the world's No. 2 player didn't come from the White House, but instead came from veteran golf journalist Tim Rosaforte, who announced it on Twitter. Rosaforte's late-morning tweet said: "The president is arriving at the Floridian range. Awaiting is Tiger Woods and club owner Jim Crane. Historic day in golf. Their first round."

White House confirmation of Woods' participation came about two hours later, following multiple appeals from traveling White House reporters.

Golf Digest reported on its website that Obama spent eight hours Saturday with Harmon, playing 27 holes and hitting balls in Harmon's studio, and then managed to coordinate Sunday's round with Woods. The report said the original plan called for Obama and Woods, a Florida resident, to play at Woods' home club ? The Medalist Golf Club, a half-hour away in Hobe Sound. But they eventually opted for the Floridian.

Woods departed after the first 18 holes, with Obama staying on to play another nine, the report said.

"Just to see the interaction between the two on the range was pretty neat," Harmon told Golf Digest. "The President said to Tiger: 'The last tournament you played was fun to watch. It's good to see you play well again.' You could tell he meant it. It just wasn't a throw it out compliment."

It seems Obama and Woods ? the first black men at the top of their respective fields ? have spent the past few years inching toward Sunday's meeting on the fairway.

They met in January 2009, during Obama's inauguration in Washington. Four months later, in April, Woods visited the White House and Obama received him in the Oval Office.

Woods' personal life imploded later in 2009 after revelations that he had engaged in multiple extramarital affairs, leading to divorce. He followed with a public apology and announced he was taking an indefinite break from golf. Shortly after Woods announced he was coming out of seclusion, Obama said in an interview with Fox News Channel that Woods will still be a "terrific" golfer despite his personal issues.

After returning to the sport, Woods went two years without winning, but his game is back on track and he currently is ranked No. 2 in the world. Woods won the last tournament he played, three weeks ago in San Diego.

The White House made clear from the start of Obama's trip that there would be no coverage of him because he would be on vacation with no plans to leave the club, which remained open to members and their guests.

It arranged for the pool of reporters who traveled with Obama to bunk at a Holiday Inn about a 20-minute drive away in Port St. Lucie. Whenever the reporters were brought to the Floridian on the off chance that Obama might leave the property, they were taken no further than a maintenance shed beyond the club gates but on the edge of the grounds.

The presence at the Floridian of a professional journalist who was tweeted about Obama's game as he was playing, while White House reporters essentially were locked out, brought a sharp response from Ed Henry, the Fox News Channel correspondent who also is president of the White House Correspondents' Association.

"A broad cross section of our members from print, radio, online and TV have today expressed extreme frustration to me about having absolutely no access to the president of the United States this entire weekend," Henry said in a statement. "There is a very simple but important principle we will continue to fight for today and in the days ahead: transparency."

In response, Earnest, the White House spokesman said: "The press access granted by the White House today is entirely consistent with the press access offered for previous presidential golf outings. It's also consistent with the press access promised to the White House Press Corps prior to arrival in Florida on Friday evening."

Previous administrations have allowed brief news media coverage at either the beginning or the end of presidential golf games. Obama's policy generally is no coverage at all, but exceptions were made for separate outings he had in 2011 with House Speaker John Boehner, R-Ohio, and former President Bill Clinton.

Golf Channel said Rosaforte is a member of the Floridian who sent his tweets from the clubhouse. Rosaforte did not have access to the course or to Obama, the network said.

Obama is in Florida while his wife and daughters are on an annual ski vacation out West. He was due to arrive back in Washington on Monday night.

___

AP Golf Writer Doug Ferguson contributed to this report.

___

Follow Darlene Superville on Twitter: http://www.twitter.com/dsupervilleap

Source: http://news.yahoo.com/tiger-woods-joins-vacationing-obama-golf-round-194013813--politics.html

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SC State University?s Sigma Delta Pi Spanish Honor Society to Host Induction Ceremony

?

SC State?s Sigma Delta Pi Spanish Honor Society will host their annual induction ceremony on Thursday, Feb.? 14, 2013 at 5 p.m. in the I.P. Stanback Museum and Planetarium.? During the induction ceremony two Spartanburg, S.C. natives, Lakesha Clawson, a senior Spanish and criminal justice major along with Loreshia Fullenwider, a junior political science major and Spanish minor will be recognized.? These students will be inducted alongside honorary members:? Dr. Cynthia Warrick, interim president of SC State University, Dr. W. Franklin Evans, vice president of Academic Affairs,? Dr. Leonard McIntyre, interim dean of the College of Education and Social Sciences, Dr. Learie Luke, associate dean and director of the Office of International Studies and Dr. Justin Niati, associate professor of French.

?

Sigma Delta Pi Spanish Honor Society was founded at the University of California, Berkeley in 1919.SC State?s Iota Omega Chapter of Sigma Delta Pi was founded on Nov. 17, 2011 with the assistance of Dr. Margaret L. Morris, associate professor of Spanish and adviser to the Spanish Honor Society. In order to be inducted into the Spanish Honor Society a student member must have completed three years (18 credit hours) of college-level Spanish and a course in Hispanic literature, or Hispanic culture and civilization by their junior year at the University. All grades earned in the six courses must be of ?A? or ?B? quality. Honorary membership is offered to any administrator or faculty member who is notably interested in and supportive of Hispanic studies.

To learn more about the Sigma Delta Pi Spanish Honor Society, contact Dr. Margaret L. Morris, at (803) 536-8847

Source: http://orangeburg.wistv.com/news/news/55450-sc-state-universitys-sigma-delta-pi-spanish-honor-society-host-induction-ceremony

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McCready's ex: Anyone close could see it coming

FILE - In this undated file photo, country singer Mindy McCready performs in Nashville, Tenn. McCready, who hit the top of the country charts before personal problems sidetracked her career, died Sunday, Feb. 17, 2013. She was 37. (AP Photo/Mark Humphrey, File)

FILE - In this undated file photo, country singer Mindy McCready performs in Nashville, Tenn. McCready, who hit the top of the country charts before personal problems sidetracked her career, died Sunday, Feb. 17, 2013. She was 37. (AP Photo/Mark Humphrey, File)

Yellow crime-scene tape blocks off the home of Mindy McCready in Heber Springs, Ark., on Monday, Feb. 18, 2013, the day after the country singer was found dead there Sunday in an apparent suicide. She was 37. (AP Photo/Jeannie Nuss)

Yellow crime-scene tape blocks off the home of Mindy McCready in Heber Springs, Ark., on Monday, Feb. 18, 2013. The country singer was found dead there Sunday in an apparent suicide. She was 37. (AP Photo/Jeannie Nuss)

Yellow crime-scene tape blocks off the front of a home in Heber Springs, Ark., where country singer Mindy McCready was found dead in an apparent suicide on Sunday, Feb. 17, 2013. She was 37. (AP Photo/Jeannie Nuss)

Yellow crime-scene tape blocks off the home of Mindy McCready in Heber Springs, Ark., on Monday, Feb. 18, 2013. The country singer was found dead there Sunday in an apparent suicide. She was 37. (AP Photo/Jeannie Nuss)

(AP) ? Mindy McCready's ex-boyfriend says she threatened to kill herself earlier this month after she lost custody of her sons, but was somehow released from rehab days before apparently following through on her threat.

Billy McKnight, a former longtime boyfriend who shares a son with the country singer, says the mother of two stayed in court-ordered substance-abuse rehabilitation for about 18 hours before checking out.

McKnight said Monday by phone from Tampa, Fla., that it was a "big mistake" to allow McCready to leave rehab, in light of her fiance David Wilson's recent suicide and the loss of her children.

McKnight is working with authorities to get his son Zander out of foster care.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-18-Obit-McCready/id-3b4a5e09ee2f4bda81ac4f35ba71ff46

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Saturday, February 16, 2013

How Saying 'NO' Grew Our Real Estate Investing Business

How Saying 'NO' Grew Our Real Estate Investing Business

Every so often, I like to circle back aroundReal Estate Investing to topics and re-illustrate a point for our readers, staff and even our clients. ?I happened to be talking to another passive real estate investment company last week and they were asking me about weeding through all the calls and requests they get from potential investors. ?They relayed that they were getting a hundred or more calls and emails a week from interested investors and often they were spending a lot of time on the phone with no real chance of helping the investor get started. ?For a myriad of reasons, the investor was not a good fit for their company. ?I pulled a line from an article I had written almost a year ago to try and help them get over their hurdle:

"In this scenario, the word 'NO' is the most powerful word a real estate
professional can include in their business. ?Developing a knack for when
to use it can be the most powerful business accelerator you have ever
implemented."

I pointed them back to the article and here is a breakdown of that article and how using no can actually lead to your ability to yes more often.

Say ?NO? More To Say ?Yes? in Your Real Estate Business

I receive emails every single week from investors who have somehow worked their way into a jam and they want to see if we can help them.? It almost always involves having purchased property sight unseen that came to them from a great referral, speaker or marketing piece disguised as a legitimate journalistic piece.? The story is always the same and there is nothing we can do to help.? The properties are invariably located in areas that we do not operate or they are so over-promised and under-delivered to the client that they are neck deep in debt with no chance to rent or sell.? These are the easy ?NO?s?.

So when I wrote that paragraph a year ago, I was talking about the easy No's. ?The times when you know an investor is asking for something that is really outside of your specialty, area of investment or there is just plain no way you can help. ?Those are the times when offering a quick ear is excellent, but trying to dig deeper is often fruitless and can lead to frustration for everyone. ?It is usually best to let someone know upfront that are not the solution and help point them in the right direction.

This was not the case with the email I received today.? It was from someone who had spoken with my company in the past.? Several times.? We were very familiar with this investor and he was asking for our help.? He had chosen to purchase properties from another company with a less than stellar reputation but at a real cheap price point, even though we had given him very direct advice on the risks when he asked for it 18 months ago.? In today?s emails he explained how he had actually purchased not one, but multiple properties here in Memphis and was having some difficulties now with poor renovations and bad property management.

Here is where it becomes very difficult.? He wanted to speak with us about managing his portfolio for him, now that the exact trouble that we had advised him on previously was occurring.? No sour grapes ? it did not matter that we had advised him that the management was poor.? It mattered that our company is not set up as a traditional management company.? Our management company is set up for the exclusive use of our clients and there is a great deal of value attached to that service.? If we were to take on this investor?s portfolio of properties ? especially since he is experiencing a lot of turnover and vacancy ? it would potentially devalue the service we offer to those clients who trusted us to provide them with properties.

This is a point that is really hard for some companies and may even be hard to tell clients sometimes. ?In this case, it was difficult but necessary and in the end, not very hard to tell a potential investor no. ?If we had said yes and helped him with his problem, there was a chance he would purchase from us. ?But experience had taught us that investors who are attracted to "cheap" are not very good fits for our business. ?As much as wanted to help, by doing so, we would be putting extra pressure on our own business to manage properties that we knew from the beginning were in poor condition, poorly renovated, and would eat up an inordinate amount of our time and resources. ?That would hurt our clients and this became an easy no.

Is There a ?Perfect Real Estate Investing Client?

We often tell interested investors that by understanding what our perfect client looks like, we are able to honestly point investors in the right direction ? even when that direction is away from our company.? It gives us the ability to say ?NO?.

I do hope that everyone reading this article really latched on to that last statement. ?It is so important if you are in this industry to understand that you cannot and should not be everything to everyone. ?If you try to head down that road and are more concerned with making money instead of doing what is right, you end up providing every potential client with a "so-so" investment and an experience that leaves a lot to be desired. ?There simply is no way to be truly great at anything if you are trying to please every single opportunity that comes along. ? ?

Feeling that you can say ?NO? when everyone around you would answer, ?YES?, is a very satisfying and freeing experience.? As a real estate professional, it means that you not only understand what makes you valuable to your clients, but it allows you to treat your most precious resources ? team members, time, cash reserves, etc. ? as the valuable assets that they are.? When you have identified your perfect client, every new program, every incentive, every marketing piece and every use of technology goes toward attracting and keeping that perfect client.? There is no more wasting time or energy searching for new clients and trying to invent new ways to keep everyone happy.? The days of hopscotching around your business and providing this for one client and that for another client are over.

You are able to focus all of your attention on providing your best service to your best clients.? Knowing from the beginning that your services do not match up well with an investors? needs ? AND BEING WILLING TO ADMIT IT ? gives you the freedom to say ?NO?.? The world is full of perfect clients?you simply have to know what they look like when you see them.

We get a lot of compliments at our company about our customer service and our property management. ?They are two things that we have zeroed in on as a company. ?Why? ?Because our clients have identified these two areas as their biggest worries. ?They have already identified for us that they want to kept in the loop, as often as possible and in a transparent way, with all the happenings of their portfolio. ?AND...they do not want us to simply rely on email. ?They want to know that someone actually cares. ?Last month we spoke directly with 489 clients on the phone. ?That inter-action is the BIGGEST reason that 63% of closed transactions last year were sold to existing clients. ?We have found the perfect clients. ?Their needs matched out expertise and we are doing business together. ?It is a beautiful thing.

No More Scarcity Mentality In Real Estate Investing

The fact remains that real estate is an extremely popular cocktail party topic and everyone wants to get involved.? Whether they can remains a different story, but the desire is there.? For some reason, many people have a romantic notion of being a real estate baron and today?s business environment has many wanting to go from dreamer to doer.? There are more opportunities today, both in terms of properties and buyers, than ever before.? If you are able to operate from an abundance mentality and lose the scarcity mentality, then telling an investor that you are not the right fit or that your service is not the best for them, becomes an easy decision to make.? Saying ?NO? becomes more about being GREAT for you perfect clients and less about making money or losing opportunity.

The biggest benefit of being willing to say ?NO? when you need to, is that your clients will thank you for it.? With the higher quality of service they receive from you because of your focus on them, they are willing to not only continue to work with you, but also refer others to your company.? The two easiest sales to make are to existing clients and to referrals from existing clients.? When they know you are willing to say ?NO? to someone else for their benefit, they will give you plenty of reasons to say ?YES?!

I read back over that statement from a year ago and, while it may seem self-serving, I am really proud that it is the true sentiment that we operate from. ?This business is a whole lot more fun when you enjoy it and enjoy who you work with both in the office and as our clients. ?It really is that simple.

We would love to hear from everyone reading this article and even encourage you to share your experience below. ?And if you are interested in talking to someone in our company and seeing if we area good fit...just click the button below!

Source: http://blog.memphisinvest.com/blog/bid/94279/How-Saying-NO-Grew-Our-Real-Estate-Investing-Business

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Scientists create method to personalize chemotherapy drug selection

Friday, February 15, 2013

In laboratory studies, scientists at the Johns Hopkins Kimmel Cancer Center have developed a way to personalize chemotherapy drug selection for cancer patients by using cell lines created from their own tumors.

If the technique is successful in further studies, it could replace current laboratory tests to optimize drug selection that have proven technically challenging, of limited use, and slow, the researchers say.

Oncologists typically choose anticancer drugs based on the affected organs' location and/or the appearance and activity of cancer cells when viewed under a microscope. Some companies offer commercial tests on surgically removed tumors using a small number of anticancer drugs. But Anirban Maitra, MBBS, professor of pathology and oncology at the Johns Hopkins University School of Medicine, says the tissue samples used in such tests may have been injured by anesthetic drugs or shipping to a lab, compromising test results.

By contrast, he says "our cell lines better and more accurately represent the tumors, and can be tested against any drug library in the world to see if the cancer is responsive."

The Johns Hopkins scientists developed their test-worthy cell lines by injecting human pancreatic and ovarian tumor cells into mice genetically engineered to favor tumor growth. Once tumors grew to one centimeter in diameter in the mice, the scientists transferred the tumors to culture flasks for additional studies and tests with anticancer drugs.

In one experiment, they successfully pinpointed the two anticancer drugs from among more than 3,000 that were the most effective in killing cells in one of the pancreatic cancer cell lines. A report on the success was published online Jan. 22 in the journal Clinical Cancer Research.

The new method was designed to overcome one of the central problems of growing human tumor cell lines in a laboratory dish -- namely the tendency of noncancerous cells in a tumor to overgrow cancerous ones, says James Eshleman, M.D., Ph.D., professor of pathology and oncology and associate director of the Molecular Diagnostics Laboratory at Johns Hopkins. As a consequence, it has not been possible to conventionally grow cell lines for some cancers. Still other cell lines, Eshleman says, don't reflect the full spectrum of disease.

To solve the problem of overcrowding by noncancerous cells, Maitra and Eshleman bred genetically engineered mice that replace the noncancerous cells with mouse cells that can be destroyed by chemicals, leaving pure human tumor cells for study.

"Our technique allows us to produce cell lines where they don't now exist, where more lines are needed, or where there is a particularly rare or biologically distinctive patient we want to study," says Eshleman.

In its proof of concept research, the Johns Hopkins team created three pancreatic ductal adenocarcinoma cell lines and one ovarian cancer cell line. They then tested one of the pancreatic cancer cell lines (called Panc502) against the Johns Hopkins Drug Library of 3,131 drugs, identifying tumor cells most responsive to the anticancer drugs digitoxin and nogalamycin.

For 30 days, they watched the effects in living mice of the two drugs and a control medicine on tumors grown from implanted cells derived from Panc502 and an additional pancreatic cell line, Panc410. They measured the size of tumors twice a week. Both drugs demonstrated more activity in reducing the tumor appearance and size in Panc502 than in Panc410, supporting the notion that the cell line technology may better predict sensitivity to the two drugs.

The investigators have given one type of their genetically engineered mice to The Jackson Laboratory in Bar Harbor, ME, a mouse genetics research facility, for breeding and distribution to other laboratories and are looking to partner with a company to distribute two other types.

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Johns Hopkins Medicine: http://www.hopkinsmedicine.org

Thanks to Johns Hopkins Medicine for this article.

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Source: http://www.labspaces.net/126826/Scientists_create_method_to_personalize_chemotherapy_drug_selection

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